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Engineering | Rege Bioengineering Lab

Google Scholar:Kaushal Rege
NCBI:Kaushal Rege

        1. Ramos, J. and Rege, K.(*)
          Comparative Investigation of Polymeric and Nanoparticle Vehicles for Transgene Delivery.
          Nano LIFE, Accepted for Publication; 2016.


        1. Elmer, J. J., Matthew D. Christensen, M. D., Barua, B., Lehrman, J., Haynes K. H., and Rege, K.(*)
          The histone deacetylase inhibitor entinostat enhances polymer-mediated transgene expression in cancer cell lines.
          Biotechnology and Bioengineering, Accepted for Publication; 2015.
        2. Pushpavanam, K., Narayanan, E., Chang, J., Sapareto, S., and Rege, K.(*)
          A Colorimetric Plasmonic Nanosensor for Dosimetry of Therapeutic Levels of Ionizing Radiation.
          ACS Nano, Accepted for Publication; 2015.
        3. Urie, R., Quraishi, S.,(#) Jaffe, M. H., and Rege, K.(*)
          Gold Nanorod-Collagen Nanocomposites for Photothermal Welding of Ruptured Porcine Intestines.
          ACS Biomaterials Science and Engineering, 2015; 1:805-815.
        4. Miryala B, Zhen Z, Potta T, Breneman C and Rege, K.(*)
          Parallel Synthesis and Quantitative Structure-Activity Relationship (QSAR) Modeling of Aminoglycoside-derived Lipopolymers for Transgene Expression.
          ACS Biomaterials Science and Engineering, 2015; 1:656-668.
        5. Miryala B, Feng Y, Omer A, Potta T and Rege, K.(*)
          Quaternization enhances the transgene expression efficacy of aminoglycoside-derived polymers.
          Int J Pharm., 2015; 489:18-29.
        6. Urie, R and Rege, K.(*)
          Nanoscale Inorganic Scaffolds as Therapeutics and Delivery Vehicles. ‘Biological Engineering 2015’
          Current Opinion in Chemical Engineering, 2015; 7:120-128.

          Professors Konstantinos Konstantopoulos and Tatiana Segura, Editors.
        7. Christensen, M. D. (+), Elmer, J. J. (+), Eaton, S., Gonzalez, L., LaBaer, J. and Rege, K.(*)
          Kinome-Level Screening Identifies Inhibition of Polo-Like Kinase-1 (PLK1) as a Target for Enhancing Non-Viral Transgene Expression.
          J. Control. Release, 2015; 204:20-29.

          (+) Equal Contributions


        1. Pushpavanam, K., Sanjitarani, S. and Rege, K.(*)
          Biotemplating Plasmonic Nanoparticles using Intact Microfluidic Vasculature of Leaves.
          Langmuir, 2014; 30(46): 14095-14103.
        2. Grandhi, T.S.P., Mallik, A., Lin, N., Miryala, B., Potta, T., Tian, Y. and Rege, K.(*)
          Aminoglycoside Antibiotic-Derived Anion-Exchange Microbeads for Plasmid DNA Binding and in Situ DNA Capture.
          ACS Appl Mater Interfaces, 2014; 6(21): 18577-18589.
        3. Grandhi, T.S.P., Potta, T., Taylor, D.J., Johnson, R.J., Tian, Y., Meldrum, D., and Rege, K.(*)
          Sensitizing Cancer Cells to TRAIL-induced Death by Micellar Delivery of Mitoxantrone.
          Nanomedicine, 2014; 9(12): 1775-1788.
        4. Ramos J, Potta T, Scheideler O and Rege, K.
          Parallel Synthesis of Poly(amino ether)-Templated Plasmonic Nanoparticles for Transgene Delivery.

          ACS Appl Mater Interfaces, 2014; 6: 14861–14873.
        5. Gosnell, H.,. Kasman, L. M., Potta, T., Vu, L., Garrett-Mayer, E., Rege, K. and Voelkel-Johnson, C.(*)
          Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer.

          J. Control. Release, 2014; 176: 35–43.
        6. Potta, T.(+), Zhen, Z.(+), Grandhi, T.S.P., Ramos J., Christensen, M., Breneman, C. M., and Rege, K.(*)
          Discovery of Antibiotics-derived Polymers for Transgene Expression using Combinatorial Synthesis and Cheminformatics Modeling.
          Biomaterials, 2014; 35(6): 1977-1988.
        7. Grandhi TS and Rege, K.
          Design, synthesis, and functionalization of nanomaterials for therapeutic drug delivery.

          Adv Exp Med Biol., 2014; 811:157-82.

(+)Equal Contributions.



        1. Huang, H-C, Walker, C. R., Nanda, A, and Rege, K.(*)
          Sutureless Laser Welding of Ruptured Intestinal Tissue using Plasmonic Nanocomposite Solders.
          ACS Nano, 2013; 7 (4):2988-2998.
        2. Walker, C.R., Pushpavanam, K., Nair ,D.G., Potta, T., Sutiyoso, C., Kodibagkar, V.K., Sapareto,S., Chang,J., and Rege, K.(*)
          Generation of Polypeptide-Templated Gold Nanoparticles using Ionizing Radiation.
          Langmuir, 2013; 29 (32):10166–10173.
        3. Elmer, J., Christensen, M. and Rege, K.(*)
          Applying Horizontal Gene Transfer Phenomena to Enhance Efficacy of Non-Viral Gene Therapy.
          J. Control Release 2013; 172 (1): 246-257.
        4. Ramos, J., and Rege, K.(*)
          Poly(aminoether)-Gold Nanorod Assemblies for Plasmid shRNA-induced Gene Silencing.
          Mol. Pharmaceutics, 2013; 10 (11): 4107–4119.



        1. Vu, L., Ramos J., Potta, T., and Rege, K.(*)
          Generation of a Focused Poly(amino ether) Library: Polymer-mediated Transgene Delivery and Gold-Nanorod based Theranostic Systems.
          Theranostics, 2012; 2(12): 1160-1173.
        2. Ramos, J., Taylor, D. J., and Rege, K.(*)
          Gold Nanoparticle-Mediated Photo-Chemotherapy
          J. Nanomed. Nanotechnol.
          2012; 3:8

        3. Borden, M and Rege, K.
          Theranostic Biocolloids: Soft Matter Colloids for Imaging and Therapy
          Theranostics, 2012(2): 1115-1116.

        4. Huang, H-C., Nanda, A., and Rege, K.(*)
          Investigation of Phase Separation Behavior and Formation of Plasmonic Nanocomposites from Polypeptide-Gold Nanorod Nanoassemblies.
          Langmuir, 2012; 28: 6645–6655.
        5. Ramos J. and Rege, K.(*)
          Transgene Delivery using Poly(aminoether)-Gold Nanorod Assemblies
          Biotechnol. Bioeng.,
          2012; 109:1336-46.
        6. Kim, J., Taylor, D.J., Agrawal, N., Wang, H., Han, A., Rege, K.(*) and Jayaraman, A(*).  
          A Programmable Microfluidic Cell Array for Combinatorial Drug Screening.

          Lab. Chip., 2012; 12: 1813 – 1822.
          This manuscript was selected for the ‘Research Highlights’ section of the journal.
        7. Labiano, A., Dai, M., Taylor, D.J., Young, W-S., Epps, T. H. III, Rege, K., and Vogt, B.D.(*)
          Slow Release Kinetics of Mitoxantrone from Ordered Mesoporous Carbon Films.
          Micropor. Mesopor. Mat., 2012; 160: 143-150.



        1. Taylor, D.J., Parsons, C.E., Han, H., Jayaraman, A., Rege, K. (*)
          Parallel Screening of FDA-Approved Antineoplastic Drugs for Identifying Sensitizers of TRAIL-induced Apoptosis in Cancer Cells.
          BMC Cancer. 2011; 11: 470.
          This manuscript is rated ‘highly accessed’ by the journal.
        2. Huang, H-C., Barua, S., Sharma, G., Dey, S. K., and Rege, K.(*)
          Inorganic Nanoparticles for Cancer Imaging and Therapy.
          J. Control. Release
          2011; 155: 344-57.
        3. Sanyal, S., Huang, H-C.,  Rege, K., and Dai, L.L.(*)
          Thermoresponsive Composite Nanoparticles Synthesized via One-Step Pickering Emulsion Polymerization for Controlled Drug Delivery.
          J Nanomedic. Nanotechnol
          . 2011, 2:126
        4. Barua, S., Ramos, J., Potta, T., Taylor, D., Huang, H-C., Montanez, G., and Rege, K.(*)
          Discovery of Cationic Polymers for Non-viral Gene Delivery using Combinatorial Approaches.
          Comb. Chem. High T. Scr.
          2011; 14: 908-924.
        5. Huang, H-C., Yang, Y., Nanda, A., Koria, P., Rege, K.(*)
          Synergistic administration of Photothermal Therapy and Chemotherapy to Cancer Cells using Polypeptide-based Degradable Plasmonic Nanomatrices.
          2011; 6: 449-458.


        1. Lin, K. C., Kunduru, V., Bothara, M., Rege, K., Prasad. S.(*), and Ramakrishna B.L.(*).
          Biogenic nanoporous silica-based sensor for enhanced electrochemical detection of cardiovascular biomarkers proteins
          Biosensors and Bioelectronics
          2010; 25: 2336-2342.
        2. Ma, H., Luo, M., Sanyal, S., Rege, K., and Dai, L.L.(*)
          The One-Step Pickering Emulsion Polymerization Route for Synthesizing Organic-Inorganic Nanocomposite Particles.

          2010; 3: 1186-1202.
        3. Barua, S. and Rege, K.(*)
          The Influence of Mediators of Intracellular Trafficking on Transgene Expression Efficacy of Polymer-Plasmid DNA Complexes
          31: 5894-5902.
        4. Huang, H-C., Heys, J.J.(*), and Rege, K.(*).
          Spatiotemporal Analysis of Temperature Response and Cancer Cell Injury following Extracellular Hyperthermia induced by Gold Nanorods.
          ACS Nano
          2010; 4: 2892-90.
        5. Chavez, V. L., Song, L., Barua, S., Li, X., Zhao, D., Rege, K., Vogt, B.D.(*)
          Impact of Nanopore Morphology on Osteoblast Viability on Mesoporous Polymer and Carbon Surfaces
          Acta Biomaterialia
          2010; 6: 3035-3043.
        6. Rege, K.(*) and Heng, M.
          Accelerated Methods Development for Recombinant Protein Purification using Miniaturized Parallel Screening
          Nat. Protocols
          2010 5:408-17
          This article has received a Faculty of 1000 Biology Citation.
        7. Barua, S., Bullard, R.S., Gamboa, J., Banerjee, I., Yarmush M. L., and Rege, K.(*)
          Lytic Peptide-Mediated Sensitization of TRAIL-Resistant
          Prostate Cancer Cells to Death Receptor Agonists.
          Cancer Lett
          . 2010; 293: 240-53.
          Equal Contributions.
        8. Chung, W-K, Evans, S.T., Freed, A.S., Keba, J.J., Baer, Z. C., Rege, K. and Cramer, S. M.
          Utilization of Lysozyme Charge Ladders to Examine the Effects of Protein Surface Charge Distribution on Binding Affinity in Ion Exchange Systems
          , 2010
        9. Huang, H-C., Ramos, J., Grandhi, T.S.P., Potta, T., and Rege, K.(*)
          Gold Nanoparticles in Cancer Imaging and Therapeutics.
          Nano LIFE
          2010; 1:


        1. Kasman, L. M., Barua, S., Lu, P., Rege, K.(*), and Voelkel-Johnson, C(*).
          Polymer-enhanced Adenoviral Transduction of CAR-negative Bladder Cancer Cells
          Mol. Pharmaceut.
          2009; 6: 1612-1619.
        2. Gulla, S., Sharma, G., Borbat, P., Freed, J., Benedikt, M.,  Holt, N., Ghimire, H. Lorigan, G., Rege, K., Mavroidis, C., and Budil, D. E.
          Molecular-scale force measurement in a coiled-coil peptide dimer by electron spin resonance.
          J. Am. Chem. Soc.
          2009; 131: 5374-+
        3. Sharma, G., Rege, K., Budil, D. E., Yarmush, M. L., and Mavroidis, C.
          Biological Force Measurement in a Protein based Nano-actuator: A Statistical Mechanics Study.
          IEEE Trans. Nanotechnol.
          2009; 8: 684-691.
        4. Huang, H-C, Barua,S., Kay, D.B., and Rege, K.(*)
          Simultaneous Enhancement of Photothermal Stability and Gene Delivery Efficacy of Gold Nanorods using Polyelectrolytes.
          ACS Nano
          2009; 3: 2941-2952.
        5. Barua, S., Joshi, A., Banerjee, A., Matthews, D., Sharfstein, S. T., Cramer, S. M., Kane, R. S., and Rege, K.(*)
          Parallel Synthesis and Screening of Polymers for Non-Viral Gene Delivery
          Mol. Pharmaceut.
          2009; 6:86-97
        6. Barua, S. and Rege, K.(*)
          Cancer Cell Phenotype Dependent Differential Intracellular Trafficking of Unconjugated Quantum Dots
          2009; 5:370-6.
          This article has received a Faculty of 1000 Biology Citation.
        7. Burdick, J., Alonas, E. Huang, H-C., Rege, K.(*),and Wang, J(*).
          High-Throughput Multisegment Synthesis of Gold Nanorods and Nanowires
          2009; 20, 65306.
        8. Sharma, G., Rege, K., Budil, D. E., Yarmush, M. L. and Mavroidis, C.
          Computational Studies of a Protein Based NanoGripper
          Int. J. Robot. Res
          .2009; 28: 421–435.


        1. Sharma, G., Rege, K., Budil, D. E., Yarmush, M. L., and Mavroidis, C.
          Reversible pH-controlled DNA Binding Peptide Nano-Tweezers: An In-Silico Study
          Int. J. Nanomed
          . 2008, 3: 505–521
        2. Huang, H-C., Koria, P., Parker, S. M., Selby, L., Megeed, Z., and Rege, K.(*)
          Optically Responsive Gold Nanorod-Polypeptide  Assemblies
          2008, 24 (24), pp 14139–14144.
        3. Li, X., Barua, S., Rege, K., and Vogt, B.D.(*)
          Tuning Stability of Mesoporous Silica Films under Biologically Relevant Conditions through Processing with Supercritical CO2.
          2008; 24:11935-41.


        1. Rege, K., Patel, S. J., Megeed, Z., and Yarmush, M. L.
          Amphipathic Peptide based Fusion Peptides and Immunoconjugates for the Targeted Ablation of Prostate Cancer Cells
          Cancer Res.
          , 2007, 67: 6368-6375.
        2. Banta, S.(+), Megeed, Z.(+), Casali, M., Rege, K., and Yarmush, M. L.
          Engineering Protein and Peptide Building Blocks for Nanotechnology
          J. Nanosci. Nanotechnol.
          , 2007, 7: 387–401.  (+)Equal contributions.


        1. Rege, K., Pepsin, M., Falcon, F., Steele, L., and Heng, M.
          High-Throughput Process Development for Purification of Recombinant Proteins.

          Biotechnol. Bioeng.
          ,2006, 93: 618-630.
          This article was second-highest downloaded article from the journal in 2006.

        2. Rege, K., Viswanathan, G., Zhu, G. Y., Vijayaraghavan, A., Ajayan, P. M., and Dordick, J. S.
          In Vitro Transcription and Protein Translation from Carbon Nanotube-DNA Assemblies.
           2006, 2: 718-722.


        1. Rege, K. (+), Ladiwala, A.(+), and Cramer S. M.
          Multi-Dimensional High-Throughput Screening of Displacers
          Anal. Chem
          2005, 77: 6818-6827.  
          Equal Contributions.
        2. Rege, K., Ladiwala, A., Hu, S., Breneman C. M., Dordick, J. S., and Cramer S. M.
          Investigation of DNA-Binding Properties of an Aminoglycoside-Polyamine Library using Quantitative Structure-Activity Relationship (QSAR) Models.

          J. Chem. Info. Mod
          .2005, 45:1854-1863.
        3. Ladiwala, A.,(+) Rege, K.,(+) Breneman, C. M., and Cramer, S. M.
          A priori prediction of adsorption isotherm parameters and chromatographic behavior in ion-exchange systems
          Proc. Natl. Acad. Sci. USA
          2005, 102: 11710–11715.

          (+) Equal Contributions.
          Featured in The Scientist, 2005.



        1. Rege, K., Hu, S., Moore, J. A., Dordick, J. S., and Cramer, S. M.
          Chemoenzymatic Synthesis and Parallel Screening of an Aminoglycoside-Polyamine Library: Identification of High Affinity Displacers and DNA-Binding Ligands
          J. Am. Chem. Soc.
          2004, 126: 12306 – 12315.
        2. Rege, K., Ladiwala, A., Tugcu, N., Breneman, C. M., and Cramer, S. M.
          Parallel Screening of Selective and High-Affinity Displacers for Proteins in Ion-Exchange Systems
          J. Chrom. A
          2004, 1033: 19-28.


        1. Ladiwala, A, Rege, K., Breneman, C. M., and Cramer, S. M.
          Investigation of Mobile Phase Salt Type Effects on Protein Retention and Selectivity in Cation Exchange Systems using Quantitative Structure-Retention Relationship Models
          2003, 19: 8443-8454.
        2. Rege, K., Raravikar, N., Kim, D.Y., Schadler, L. S., Ajayan, P. M., and Dordick, J. S.
          Enzyme-Polymer-Single Walled Carbon Nanotube Composites as Biocatalytic Films
          Nano Lett.
          2003, 3: 829-832.
        3. Rege, K., Tugcu, N., and Cramer, S.M.
          Predicting Column Performance in Displacement Chromatography from High Throughput Screening Experiments
          Sep. Sci. Tech.
          2003, 38: 1499-1519.


        1. Mazza, C. B.,(+) Rege, K.,(+) Breneman, C. M., Sukumar, N., Dordick, J. S., and Cramer, S. M.
          High Throughput Screening and Quantitative Structure-Efficacy Relationship Models of Potential Displacer Molecules for Ion-Exchange Systems
          Biotechnol. Bioeng.
          2002, 80: 60-73.

          (+)Equal Contributions.
        2. Pydi Setty, Y., Rege, K., and Sastry, C.
          A Model for Residence Time Distribution of Solids in a Fluidized Bed
          Indian Chem. Eng.
          2002, 44: 246-251.