We have interfaced thermally responsive polypeptides with gold nanorods resulting in assemblies and composites that can be manipulated by near infrared radiation. We have employed these materials for simultaneous adminsitration of hyperthermia and chemotherapeutic drugs to cancer cells. We are currently carrying out a fundamental investigation into how different polypeptide-nanomaterial composites respond to radiation.
NANOPARTICLE-POLYMER ASSEMBLIES FOR NUCLEIC ACID DELIVERY
Cationic polymers are interfaced with gold nanorods resulting in stable nanoassemblies capable of simultaneous administration of hyperthermia and nucleic acid delivery to cancer cells. We are investigating these assemblies for transgene delivery and gene silencing.
POLYMERIC MICELLES FOR DRUG DELIVERY
We are generating novel polymeric micelles (20-150 nm diameter) for delivering chemotherapeutic drugs to cancer cells